{"id":886,"date":"2021-02-28T14:05:23","date_gmt":"2021-02-28T14:05:23","guid":{"rendered":"https:\/\/www.step3.net\/?p=886"},"modified":"2026-07-25T07:21:29","modified_gmt":"2026-07-25T07:21:29","slug":"sars-cov-2%e3%81%8c%e5%ae%bf%e4%b8%bb%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e5%85%8d%e7%96%ab%e9%98%b2%e5%be%a1%e3%82%b7%e3%82%b9%e3%83%86%e3%83%a0%e3%82%92%e9%98%bb%e5%ae%b3%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.step3.net\/?p=886","title":{"rendered":"SARS-CoV-2\u304c\u5bbf\u4e3b\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u514d\u75ab\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3092\u963b\u5bb3\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u89e3\u660e\u3055\u308c\u308b"},"content":{"rendered":"<p><a href=\"https:\/\/www.step3.net\/wp-content\/uploads\/2026\/07\/nejmcibr2007042_f1.jpeg\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" border=\"0\" alt=\"Nejmcibr2007042_f1\" title=\"Nejmcibr2007042_f1\" style=\"margin: 3px;\" src=\"https:\/\/www.step3.net\/wp-content\/uploads\/2026\/07\/nejmcibr2007042_f1.jpg\" width=\"300\" height=\"320\"><\/a><br \/>\n\u51fa\u5178\uff1a<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMcibr2007042\" target=\"_blank\">How to Discover Antiviral Drugs Quickly(The NewEngland Journal of Medicine<\/a><br \/>\n\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7COVID-19\u306f\u3001\u4eba\u4f53\u304c\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9SARS-CoV-2\u306b\u611f\u67d3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3002<br \/>\n\u305d\u306e\u4e8b\u5b9f\u3092\u5b66\u3073\u3001\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u95a2\u3059\u308b\u77e5\u8b58\u3092\u6025\u901f\u306b\u7fd2\u5f97\u3057\u59cb\u3081\u3066\u3002\u3082\u3046\u3059\u3050\u4e00\u5e74\u3002SARS-CoV-2\u306b\u5bfe\u5fdc\u3059\u308b\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u304c\u3001\u65e5\u672c\u3067\u306e\u533b\u7642\u95a2\u4fc2\u8005\u3084\u9ad8\u9f62\u8005\u304c\u5148\u884c\u3059\u308b\u304c\u59cb\u307e\u3063\u305f\u3002<br \/>\n\u3057\u304b\u3057\u3001SARS-CoV-2\u30a6\u30a4\u30eb\u30b9\u306e\u304a\u59ff\u3068\u3044\u3046\u3068\u3001\u30a4\u30ac\u30a4\u30ac\u306e\u3064\u3044\u305f\u7403\u4f53\u304c\u6709\u540d\u3060\u3051\u3069\u3001\u305d\u306e\u5185\u90e8\u3092\u4e00\u822c\u3080\u3051\u306b\u30ad\u30c1\u30f3\u3068\u8aac\u660e\u3057\u3066\u3044\u308b\u60c5\u5831\u306f\u610f\u5916\u3068\u5c11\u306a\u3044\u3002The New England Journal of Medicnie\u304c\u3001\u305d\u306e\u3001\u6bd2\u3005\u3057\u3044\u59ff\u3092\u7d39\u4ecb\u3057\u3066\u304f\u308c\u3066\u3044\u305f\u3002\u78ba\u304b\u306b\u3001\u6c17\u6301\u3061\u304c\u60aa\u3044\u3002<br \/>\n<a href=\"https:\/\/www.igakuken.or.jp\/r-info\/covid-19-info9.html\" target=\"_blank\">\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u6771\u4eac\u90fd\u533b\u5b66\u7dcf\u5408\u7814\u7a76\u6240\u306e\u767a\u8868(2020\/07\/28\uff09<\/a>\u306b\u3088\u308b\u3068\u3001SARS-CoV-2\u304c\u5bbf\u4e3b\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u514d\u75ab\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3092\u963b\u5bb3\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3055\u308c\u305f\u3089\u3057\u3044\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u809d\u3068\u306a\u308bNsp1\u3092\u6a19\u7684\u3068\u3057\u305f\u5275\u85ac\u306f\u3001SARS-CoV-2\u306e\u514d\u75ab\u6291\u5236\u3092\u89e3\u9664\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u514d\u75ab\u6392\u9664\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u671f\u5f85\u3067\u304d\u308b\u3089\u3057\u3044\u3002<br \/>\n\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u306b\u3068\u3063\u3066\u3001\u5bbf\u4e3b\u306e\u514d\u75ab\u6392\u9664\u30b7\u30b9\u30c6\u30e0\u3092\u56de\u907f\u3059\u308b\u6226\u7565\u306e\u7372\u5f97\u306f\u5927\u5909\u91cd\u8981\u3002SARS-CoV-2\u3067\u306f\u3001Nsp(Non structured protein)\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u5bbf\u4e3b\u7d30\u80de\u306e\u5897\u6b96\u6291\u5236\u306b\u95a2\u308f\u308b\u6a5f\u80fd\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u3089\u3057\u3044\uff08virulence factor; \u6bd2\u6027\u56e0\u5b50\uff09\u3002<br \/>\n\u3055\u3089\u306b\u3001\u3053\u306e\u8ad6\u6587\u4e2d\u3067\u7d39\u4ecb\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/science.sciencemag.org\/content\/early\/2020\/07\/16\/science.abc8665\" target=\"_blank\">2020\/7\/17\u3001Science\u767a\u8868\u8ad6\u6587<\/a>\u306b\u3088\u308b\u3068\u3001SARS-CoV-2\u30b2\u30ce\u30e0\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b26\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e2d\u306e\u4e00\u3064Nsp1\u304c\u3001\u5bbf\u4e3b\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306b\u5fc5\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u3092\u7279\u7570\u7684\u306b\u30b7\u30e3\u30c3\u30c8\u30c0\u30a6\u30f3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5bbf\u4e3b\u306e\u514d\u75ab\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002<br \/>\nNsp1\u306f\u3001\u30ea\u30dc\u30bd\u30fc\u30e040S\u304a\u3088\u307380S\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u4e21\u8005\u306b\u7d50\u5408\u3057\u3001mRNA\u306e\u4fb5\u5165\u90e8\u4f4d(entry site)\u306e\u5185\u90e8\u306b\u56fa\u304f\u7d50\u5408\u3057\u3001mRNA\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3057\u3001\u7ffb\u8a33\u958b\u59cb\u3092\u963b\u5bb3\u3059\u308b\u3002\u5177\u4f53\u7684\u306b\u306f\u3001RIG-1\uff08\u30a6\u30a4\u30eb\u30b9\u304c\u7d30\u80de\u5185\u306b\u9032\u5165\u3057\u305f\u6642\u306b\u30a6\u30a4\u30eb\u30b9\u7531\u6765\u306eRNA\u3092\u8a8d\u8b58\u3057\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u4f5c\u7528\u3092\u793a\u3059I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u7523\u751f\u306e\u8a98\u5c0e\u3092\u5f15\u304d\u8d77\u3053\u3059\u56e0\u5b50\uff09\u3084ISGs(\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u907a\u4f1d\u5b50)\u306e\u7ffb\u8a33\u3092\u5f37\u304f\u963b\u5bb3\u3057\u3001\u514d\u75ab\u6392\u9664\u3092\u56de\u907f\u3059\u308b\u3068\u3044\u3046\u30b7\u30b9\u30c6\u30e0\u3092\u6709\u3059\u308b\u3002\u5de7\u5999\u3060\u3002<br \/>\nNsp1\u305d\u306e\u3082\u306e\u306e\u50cd\u304d\u3092\u9632\u5fa1\u3059\u308b\u6226\u7565\u3084\u3001SARS-CoV-2\u306eRNA\u306b\u5bfe\u3057\u3066\u3001Nsp1\u306e\u3088\u3046\u306a\u7269\u8cea\u3092\u7528\u3044\u3066\u3001RNA\u306e\u8907\u88fd\u3092\u6b62\u3081\u3066\u3057\u307e\u3046\u6226\u7565\u304c\u8003\u3048\u3089\u308c\u308b\u3001\u305d\u3093\u306a\u6226\u7565\u3092\u5b9f\u884c\u3067\u304d\u308b\u5316\u5b66\u7269\u8cea\u306f\u306a\u3044\u306e\u304b\uff1f<br \/>\n\u305d\u308c\u306b\u3057\u3066\u3082\u3001\u3082\u306e\u51c4\u304f\u5c0f\u3055\u306a\u30b9\u30b1\u30fc\u30eb\u3067\u306e\u51fa\u6765\u4e8b\u3092\u4f1a\u8a71\u3057\u3066\u3044\u308b\u3002\u3059\u3054\u3044\u3001\u6642\u4ee3\u3060\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u51fa\u5178\uff1aHow to Discover Antiviral Drugs Quickly(The NewEngland Journal of Medicine \u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7COVID-19\u306f\u3001\u4eba\u4f53\u304c\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-886","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.step3.net\/index.php?rest_route=\/wp\/v2\/posts\/886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.step3.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.step3.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.step3.net\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.step3.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=886"}],"version-history":[{"count":1,"href":"https:\/\/www.step3.net\/index.php?rest_route=\/wp\/v2\/posts\/886\/revisions"}],"predecessor-version":[{"id":1651,"href":"https:\/\/www.step3.net\/index.php?rest_route=\/wp\/v2\/posts\/886\/revisions\/1651"}],"wp:attachment":[{"href":"https:\/\/www.step3.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.step3.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.step3.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}